Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases.
Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases.
Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases.
Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference.
Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics.
Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis.
Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology.
Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Edited by Marc C. Hochberg, MD, MPH, MACP, Professor of Medicine and Epidemiology and Public Health; Head, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA ; Josef S. Smolen, MD, FRCP, Professor of Medicine, Chairman, Department of Medicine III, Division of Rheumatology, Medical University of Vienna;Chairman, Second Department of Medicine, Center for Rheumatic Diseases, Hietzing Hospital, Vienna, Austria ; Michael E. Weinblatt, MD, John R. and Eileen K. Riedman Professor of Medicine, Harvard Medical School; R. Bruce and Joan M. Mickey Distinguished Chair in Rheumatology, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, USA ; Michael H. Weisman, MD, Cedars-Sinai Chair in Rheumatology, Director, Division of Rheumatology, Professor of Medicine, Cedars-Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA ; Ellen M Gravallese, MD, Professor of Medicine, University of Massachusetts Medical School, Division of Rheumatology; Director of Translational Research, Musculoskeletal Center of Excellence, University of Massachusetts Medical School and University of Massachusetts Memorial Medical Center; Myles J. McDonough Chair in Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts and Desiree van der Heijde, Professor of Rheumatology; University Hospital Maastricht; Maastricht, Netherlands
Section 1: The Scientific Basis of Rheumatic Disease 1. Epidemiologic concepts and the classification of rheumatic and musculoskeletal conditions
2. Principles of clinical outcome assessment
3. Principles of health economics and application to rheumatic disorders
4. The synovium
5. The articular cartilage
6. Bone structure and function
7. Tendons and ligaments
8. Connective tissue responses to mechanical stresses
9. Biomechanics of peripheral joints
10. Biomechanics of the spine
11. Principles of genetic epidemiology
12. Principles and techniques in molecular biology
14. Signal transduction in immune cells
15. The principles of adaptive immunity
16. Principles of innate immunity
17. Systems biology
18. Epigenetics in Rheumatology
19. The microbiome in rheumatic diseases
20. Tissue destruction and repair
21. Principles of tissue engineering and cell- and gene-based therapy
23. Inflammation and its mediators
24. Scientific basis of pain
25. Effects of the neuroendocrine system on development and function of the immune system
26. Interpreting the medical literature for the rheumatologist: study design and levels of evidence
27. Ethics in clinical trials Section 2: Clinical Basis of Rheumatic Disease
28. History and physical examination
29. Pattern recognition in arthritis
30. Role of laboratory tests in rheumatic disorders
31. Synovial fluid analysis
32. Minimally invasive procedures
33. Skin in rheumatic disease
34. The eye in rheumatic disease
35. The heart in rheumatic disease
36. The lung in rheumatic disease
37. Gastrointestinal tract and rheumatic disease
38. The kidney and rheumatic disease
39. The nervous system in rheumatic disease
Section 3: Evaluation: Imaging Techniques
40. Conventional radiography and computed tomography
41. Functional magnetic resonance imaging
42. Musculoskeletal ultrasound
43. Bone scintigraphy and positron emission tomography
44. Dual x-ray absorptiometry and measurement of bone
45. Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trials
Section 4: Principles of Management
46. Arthritis patient education, health promotion, and team approaches to management
47. Principles of rehabilitation: physical and occupational therapy
48a. Complementary and alternative medicine
48b. Placebos, Caring and Healing in Rheumatology
49. Drug Development
50. Non-pharmacologic pain management
51. Pharmacogenomics in rheumatology
52. Principles of opioid treatment of chronic musculoskeletal pain