Harrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text―and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine.
Written and edited by the world’s top experts in their respective fields, this landmark guide provides comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease.
Harrison’s is world-renowned as the most authoritative source for:
•Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases • The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow • Updated clinical trial results and recommended guidelines • Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings • Coverage of both therapeutic approaches and specific treatment regimens • Practical clinical decision trees and algorithms • Organ/system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, and general and specific approaches to therapy
Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition:
•Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer • Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries • More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes • Numerous atlases featuring curated collections of important visual aspects of diagnosis and management • Updated and time-saving curation and synthesis of established and new medical literature and studies • Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms
Part 1: The Profession of Medicine Updated! Chapter 1: The Practice of Medicine Updated! Chapter 2: Promoting Good Health Updated! Chapter 3: Vaccine Opposition and Hesitancy Updated! Chapter 4: Decision-Making in Clinical Medicine Updated! Chapter 5: Precision Medicine and Clinical Care New! Chapter 6: Screening and Prevention of Disease Updated! Chapter 7: Global Diversity of Health System Financing and Delivery Updated! Chapter 8: The Safety and Quality of Health Care Updated! Chapter 9: Diagnosis: Reducing Errors and Improving Quality New! Chapter 10: Racial and Ethnic Disparities in Health Care Updated! Chapter 11: Ethical Issues in Clinical Medicine New! Chapter 12: Palliative and End-of-Life Care Part 2: Cardinal Manifestations and Presentation of Diseases Section 1: Pain New! Chapter 13: Pain: Pathophysiology and Management New! Chapter 14: Chest Discomfort New! Chapter 15: Abdominal Pain New! Chapter 16: Headache New! Chapter 17: Back and Neck Pain Section 2: Fever New! Chapter 18: Fever New! Chapter 19: Fever and Rash New! Chapter 20: Fever of Unknown Origin Section 3: Nervous System Dysfunction New! Chapter 21: Syncope Updated! Chapter 22: Dizziness and Vertigo New! Chapter 23: Fatigue New! Chapter 24: Neurologic Causes of Weakness and Paralysis New! Chapter 25: Numbness, Tingling, and Sensory Loss New! Chapter 26: Gait Disorders, Imbalance, and Falls Updated! Chapter 27: Confusion and Delirium New! Chapter 28: Coma New! Chapter 29: Dementia New! Chapter 30: Aphasia, Memory Loss, and Other Cognitive Disorders New! Chapter 31: Sleep Disorders Section 4: Disorders of Eyes, Ears, Nose, and Throat New! Chapter 32: Disorders of the Eye New! Chapter 33: Disorders of Smell and Taste New! Chapter 34: Disorders of Hearing New! Chapter 35: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat New! Chapter 36: Oral Manifestations of Disease Section 5: Alterations in Circulatory and Respiratory Functions New! Chapter 37: Dyspnea New! Chapter 39: Hemoptysis New! Chapter 38: Cough New! Chapter 40: Hypoxia and Cyanosis New! Chapter 41: Edema New! Chapter 43: Palpitations Section 6: Alterations in Gastrointestinal Function New! Chapter 44: Dysphagia New! Chapter 45: Nausea, Vomiting, and Indigestion New! Chapter 46: Diarrhea and Constipation New! Chapter 47: Unintentional Weight Loss Updated! Chapter 48: Gastrointestinal Bleeding New! Chapter 49: Jaundice Updated! Chapter 50: Abdominal Swelling and Ascites Section 7: Alterations in Renal and Urinary Tract Function New! Chapter 51: Interstitial Cystitis/Bladder Pain Syndrome New! Chapter 52: Azotemia and Urinary Abnormalities New! Chapter 54: Hypercalcemia and Hypocalcemia New! Chapter 55: Acidosis and Alkalosis Section 8: Alterations in the Skin New! Chapter 56: Approach to the Patient with a Skin Disorder New! Chapter 57: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders New! Chapter 58: Skin Manifestations of Internal Disease New! Chapter 59: Immunologically Mediated Skin Diseases New! Chapter 60: Cutaneous Drug Reactions New! Chapter 61: Photosensitivity and Other Reactions to Sunlight Section 9: Hematologic Alterations New! Chapter 62: Interpreting Peripheral Blood Smears New! Chapter 63: Anemia and Polycythemia New! Chapter 64: Disorders of Granulocytes and Monocytes New! Chapter 65: Bleeding and Thrombosis New! Chapter 66: Enlargement of Lymph Nodes and Spleen Part 3: Pharmacology New! Chapter 67: Principles of Clinical Pharmacology Updated! Chapter 68: Pharmacogenomics Part 4: Oncology and Hematology Section 1: Neoplastic Disorders New! Chapter 70: Prevention and Early Detection of Cancer New! Chapter 71: Cancer Genetics New! Chapter 72: Cancer Cell Biology New! Chapter 73: Principles of Cancer Treatment New! Chapter 75: Oncologic Emergencies New! Chapter 76: Cancer of the Skin New! Chapter 77: Head and Neck Cancer New! Chapter 80: Upper Gastrointestinal Tract Cancers New! Chapter 81: Lower Gastrointestinal Cancers New! Chapter 82: Tumors of the Liver and Biliary Tree New! Chapter 85: Renal Cell Carcinoma New! Chapter 86: Cancer of the Bladder and Urinary Tract New! Chapter 87: Benign and Malignant Diseases of the Prostate New! Chapter 88: Testicular Cancer New! Chapter 89: Gynecologic Malignancies New! Chapter 90: Primary and Metastatic Tumors of the Nervous System New! Chapter 91: Soft Tissue and Bone Sarcomas and Bone Metastases New! Chapter 93: Paraneoplastic Syndromes: Endocrinologic/Hematologic New! Chapter 95: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment Section 2: Hematopoietic Disorders New! Chapter 96: Hematopoietic Stem Cells New! Chapter 97: Iron Deficiency and Other Hypoproliferative Anemias New! Chapter 99: Megaloblastic Anemias New! Chapter 101: Anemia Due to Acute Blood Loss New! Chapter 102: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia New! Chapter 103: Polycythemia Vera and Other Myeloproliferative Neoplasms New! Chapter 105: Chronic Myeloid Leukemia New! Chapter 108: Non-Hodgkin’s Lymphoma New! Chapter 109: Hodgkin’s Lymphoma New! Chapter 112: Amyloidosis New! Chapter 113: Transfusion Therapy and Biology New! Chapter 114: Hematopoietic Cell Transplantation Section 3: Disorders of Hemostasis New! Chapter 115: Disorders of Platelets and Vessel Wall New! Chapter 118: Antiplatelet, Anticoagulant, and Fibrinolytic Drugs Part 5: Infectious Diseases Section 2: Clinical Syndromes: Community-Acquired Infections New! Chapter 126: Pneumonia New! Chapter 138: Acute Meningitis New! Chapter 139: Chronic and Recurrent Meningitis New! Chapter 140: Brain Abscess and Empyema New! Chapter 141: Infectious Complications of Bites Section 3: Clinical Syndromes: Health Care-Associated Infections New! Chapter 142: Infections Acquired in Health Care Facilities New! Chapter 143: Infections in Transplant Recipients Section 4: Therapy for Bacterial Diseases New! Chapter 144: Treatment and Prophylaxis of Bacterial Infections New! Chapter 145: Bacterial Resistance to Antimicrobial Agents Section 5: Diseases Caused by Gram-Positive Bacteria New! Chapter 146: Pneumococcal Infections New! Chapter 147: Staphylococcal Infections New! Chapter 148: Streptococcal Infections New! Chapter 149: Enterococcal Infections New! Chapter 150: Diphtheria and Other Corynebacterial Infections New! Chapter 151: Listeria monocytogenes Infections New! Chapter 152: Tetanus New! Chapter 153: Botulism New! Chapter 154: Gas Gangrene and Other Clostridial Infections Section 6: Diseases Caused by Gram-Negative Bacteria New! Chapter 155: Meningococcal Infections New! Chapter 157: Haemophilus and Moraxella Infections New! Chapter 158: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria New! Chapter 159: Legionella Infections New! Chapter 160: Pertussis and Other Bordetella Infections New! Chapter 161: Diseases Caused by Gram-Negative Enteric Bacilli New! Chapter 162: Acinetobacter Infections Part 7: Disorders of the Respiratory System Section 1: Diagnosis of Respiratory Disorders New! Chapter 284: Approach to the Patient with Disease of the Respiratory System New! Chapter 285: Disturbances of Respiratory Function Section 2: Diseases of the Respiratory System New! Chapter 288: Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia Part 9: Disorders of the Kidney and Urinary Tract New! Chapter 309: Cell Biology and Physiology of the Kidney New! Chapter 312: Dialysis in the Treatment of Kidney Failure New! Chapter 314: Glomerular Diseases New! Chapter 315: Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development New! Chapter 317: Vascular Injury to the Kidney New! Chapter 318: Nephrolithiasis New! Chapter 319: Urinary Tract Obstruction New! Chapter 320: Interventional Nephrology Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders Section 2: Disorders of Immune-Mediated Injury New! Chapter 353: Anaphylaxis New! Chapter 354: Mastocytosis New! Chapter 357: Antiphospholipid Syndrome New! Chapter 361: Sjögren’s Syndrome New! Chapter 364: Behçet Syndrome Part 12: Endocrinology and Metabolism Section 1: Endocrinology New! Chapter 383: Hypothyroidism Part 13: Neurologic Disorders Section 2: Diseases of the Central Nervous System New! Chapter 431: Alzheimer’s Disease